5A46

FGFR1 in complex with dovitinib

Summary for 5A46

Entry DOI	10.2210/pdb5a46/pdb
Related	5A4C
Descriptor	FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B, 1,2-ETHANEDIOL, 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one, ... (5 entities in total)
Functional Keywords	transferase, kinase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	88561.19
Authors	Klein, T.,Vajpai, N.,Phillips, J.J.,Davies, G.,Holdgate, G.A.,Phillips, C.,Tucker, J.A.,Norman, R.A.,Scott, A.S.,Higazi, D.R.,Lowe, D.,Thompson, G.S.,Breeze, A.L. (deposition date: 2015-06-05, release date: 2015-08-05)
Primary citation	Klein, T.,Vajpai, N.,Phillips, J.J.,Davies, G.,Holdgate, G.A.,Phillips, C.,Tucker, J.A.,Norman, R.A.,Scott, A.D.,Higazi, D.R.,Lowe, D.,Thompson, G.S.,Breeze, A.L. Structural and Dynamic Insights Into the Energetics of Activation Loop Rearrangement in Fgfr1 Kinase. Nat.Commun., 6:7877-, 2015 Cited by PubMed: 26203596 DOI: 10.1038/NCOMMS8877 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.63 Å)

Structure validation