5A46

FGFR1 in complex with dovitinib

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	DIAMOND BEAMLINE I04
Synchrotron site	Diamond
Beamline	I04
Temperature [K]	100
Detector technology	CCD
Detector	ADSC QUANTUM 315
Spacegroup name	C 1 2 1
Unit cell lengths	209.800, 56.830, 65.740
Unit cell angles	90.00, 107.36, 90.00

Refinement procedure

Resolution	62.750 - 2.630
R-factor	0.1819
Rwork	0.178
R-free	0.24590
Structure solution method	OTHER
RMSD bond length	0.010
RMSD bond angle	1.140
Data reduction software	XDS
Refinement software	BUSTER (2.11.5)

Data quality characteristics

	Overall	Outer shell
Low resolution limit [Å]	62.750	2.940
High resolution limit [Å]	2.630	2.630
Rmerge	0.070
Number of reflections	21568
<I/σ(I)>	12.3
Completeness [%]	97.1	98.9
Redundancy	3.4

Crystallization Conditions

crystal ID	method	pH	temperature	details
1				20% PEG8000, 20MM AMMONIUM SULPHATE, 20% ETHYLENE GLYCOL, 100MM PCTP PH6.7.