5A4C
FGFR1 ligand complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | FIBROBLAST GROWTH FACTOR RECEPTOR 1 (FMS-RELATED TYROSINE KINASE 2, PFEIFFER SYNDROME), ISOFORM CRA_B | polymer | 307 | 34979.2 | 2 | UniProt (P11362) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | FGFR1 |
| 2 | C, D, E, F, L... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 3 | G, H, I, J, M... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 4 | K, T (A, B) | 1-tert-butyl-3-[2-[3-(diethylamino)propylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea | non-polymer | 509.6 | 2 | Chemie (XOJ) | |||
| 5 | U, V (A, B) | water | water | 18.0 | 347 | Chemie (HOH) |
Sequence modifications
A, B: 461 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Gly 459 | - | expression tag |
| Ala 460 | - | expression tag |
| Ala 488 | Cys 488 | engineered mutation |
| Ser 584 | Cys 584 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69958.3 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2216.3 | |
| All* | Total formula weight | 72174.7 |
