5YOY
Crystal structure of the human tumor necrosis factor in complex with golimumab Fv
Summary for 5YOY
Entry DOI | 10.2210/pdb5yoy/pdb |
Descriptor | Tumor necrosis factor, Golimumab light chain variable region, Golimumab heavy chain variable region, ... (4 entities in total) |
Functional Keywords | cytokine, antibody, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 18 |
Total formula weight | 279323.32 |
Authors | Ono, M.,Horita, S.,Sato, Y.,Nomura, Y.,Iwata, S.,Nomura, N. (deposition date: 2017-10-31, release date: 2018-05-09, Last modification date: 2023-11-22) |
Primary citation | Ono, M.,Horita, S.,Sato, Y.,Nomura, Y.,Iwata, S.,Nomura, N. Structural basis for tumor necrosis factor blockade with the therapeutic antibody golimumab Protein Sci., 27:1038-1046, 2018 Cited by PubMed: 29575262DOI: 10.1002/pro.3407 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.727 Å) |
Structure validation
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