5YOY
Crystal structure of the human tumor necrosis factor in complex with golimumab Fv
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, J, K... (A, B, C, J, K...) | Tumor necrosis factor | polymer | 173 | 19350.7 | 6 | UniProt (P01375) Pfam (PF00229) | Homo sapiens (Human) | Cachectin,TNF-alpha,Tumor necrosis factor ligand superfamily member 2,TNF-a |
| 2 | D, E, F, M, N... (D, E, F, M, N...) | Golimumab light chain variable region | polymer | 119 | 13022.4 | 6 | Homo sapiens | ||
| 3 | G, H, I, P, Q... (G, H, I, P, Q...) | Golimumab heavy chain variable region | polymer | 129 | 14180.8 | 6 | Homo sapiens | ||
| 4 | AA, BA, CA, DA, EA... (I, J, K, L, M...) | water | water | 18.0 | 86 | Chemie (HOH) |
Sequence modifications
A, B, C, J, K, L: 1 - 157 (UniProt: P01375)
| PDB | External Database | Details |
|---|---|---|
| Asp -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Lys 0 | - | cloning artifact |
| Thr 158 | - | cloning artifact |
| Ser 159 | - | cloning artifact |
| Glu 160 | - | cloning artifact |
| Asn 161 | - | cloning artifact |
| Leu 162 | - | cloning artifact |
| Tyr 163 | - | cloning artifact |
| Phe 164 | - | cloning artifact |
| Gln 165 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 279323.3 | |
| All* | Total formula weight | 279323.3 |
