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5YOY

Crystal structure of the human tumor necrosis factor in complex with golimumab Fv

Functional Information from GO Data
ChainGOidnamespacecontents
A0005164molecular_functiontumor necrosis factor receptor binding
A0006955biological_processimmune response
A0016020cellular_componentmembrane
B0005164molecular_functiontumor necrosis factor receptor binding
B0006955biological_processimmune response
B0016020cellular_componentmembrane
C0005164molecular_functiontumor necrosis factor receptor binding
C0006955biological_processimmune response
C0016020cellular_componentmembrane
J0005164molecular_functiontumor necrosis factor receptor binding
J0006955biological_processimmune response
J0016020cellular_componentmembrane
K0005164molecular_functiontumor necrosis factor receptor binding
K0006955biological_processimmune response
K0016020cellular_componentmembrane
L0005164molecular_functiontumor necrosis factor receptor binding
L0006955biological_processimmune response
L0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00251
Number of Residues17
DetailsTHD_1 Tumor necrosis factor (TNF) homology domain (THD) signature. LvVPsEGLYLIysQVlF
ChainResidueDetails
ALEU48-PHE64

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsSITE: Cleavage; by ADAM17
ChainResidueDetails
ALYS0
BLYS0
CLYS0
JLYS0
KLYS0
LLYS0

site_idSWS_FT_FI2
Number of Residues6
DetailsCARBOHYD: O-linked (GalNAc...) serine; in soluble form => ECO:0000269|PubMed:8631363
ChainResidueDetails
ASER4
BSER4
CSER4
JSER4
KSER4
LSER4

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PDB entries from 2024-07-24

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