5YBF
Crystal structure of the GluA2o LBD in complex with glutamate and HBT1
Summary for 5YBF
Entry DOI | 10.2210/pdb5ybf/pdb |
Descriptor | Glutamate receptor 2,Glutamate receptor 2, GLUTAMIC ACID, 2-[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanoylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, ... (6 entities in total) |
Functional Keywords | ampa receptor ligand-binding domain, allosteric modulation complex, membrane protein, transport protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Multi-pass membrane protein : P42262 |
Total number of polymer chains | 6 |
Total formula weight | 178841.11 |
Authors | Sogabe, S.,Igaki, S.,Hirokawa, A.,Zama, Y.,Lane, W.,Snell, G. (deposition date: 2017-09-04, release date: 2018-01-17, Last modification date: 2023-11-22) |
Primary citation | Kunugi, A.,Tajima, Y.,Kuno, H.,Sogabe, S.,Kimura, H. HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production. J. Pharmacol. Exp. Ther., 364:377-389, 2018 Cited by PubMed: 29298820DOI: 10.1124/jpet.117.245050 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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