5Y66

Crystal structure of Pseudomonas fluorescens Kynurenine 3-monooxygenase in complex with L-KYN and Ro61-8048

Summary for 5Y66

• Entry DOI: 10.2210/pdb5y66/pdb
• Descriptor: Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide, ... (5 entities in total)
• Functional Keywords: kmo, inhibitor, l-kyn, ro 61-8048, oxidoreductase
• Biological source: Pseudomonas fluorescens
• Total number of polymer chains: 1
• Total formula weight: 53528.28

Authors

Xiang, Y.,Gao, J.J.,Zhu, D.Y. (deposition date: 2017-08-10, release date: 2017-12-27, Last modification date: 2024-03-27)

• Primary citation: Gao, J.,Yao, L.,Xia, T.,Liao, X.,Zhu, D.,Xiang, Y.; Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048; FASEB J., 32:2036-2045, 2018; PubMed: 29208702; DOI: 10.1096/fj.201700397RR

Experimental method

X-RAY DIFFRACTION (2.34 Å)