5Y66

Crystal structure of Pseudomonas fluorescens Kynurenine 3-monooxygenase in complex with L-KYN and Ro61-8048

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004497	molecular_function	monooxygenase activity
A	0004502	molecular_function	kynurenine 3-monooxygenase activity
A	0006569	biological_process	L-tryptophan catabolic process
A	0009435	biological_process	NAD+ biosynthetic process
A	0016174	molecular_function	NAD(P)H oxidase H2O2-forming activity
A	0016491	molecular_function	oxidoreductase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0019674	biological_process	NAD+ metabolic process
A	0019805	biological_process	quinolinate biosynthetic process
A	0043420	biological_process	anthranilate metabolic process
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0070189	biological_process	kynurenine metabolic process
A	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	binding site for residue FAD A 501

Chain	Residue
A	ILE13
A	ALA56
A	ARG111
A	LEU133
A	GLY134
A	LEU135
A	ALA165
A	ASP166
A	GLY167
A	TYR193
A	GLY310
A	ALA15
A	ASP311
A	PRO318
A	GLY321
A	GLN322
A	GLY323
A	MET324
A	ASN325
A	KYN503
A	HOH621
A	HOH623
A	GLY16
A	HOH634
A	HOH652
A	LEU17
A	ALA18
A	GLU37
A	ARG38
A	ARG39
A	LEU55

---

site_id	AC2
Number of Residues	13
Details	binding site for residue 7ZR A 502

Chain	Residue
A	ARG84
A	GLU372
A	TYR382
A	GLU385
A	ARG386
A	GLY389
A	PRO402
A	ARG403
A	TYR404
A	GLY421
A	GLN424
A	GLU425
A	LEU428

---

site_id	AC3
Number of Residues	11
Details	binding site for residue KYN A 503

Chain	Residue
A	ARG84
A	LEU213
A	PHE238
A	PRO318
A	PHE319
A	HIS320
A	GLY321
A	ASN369
A	MET373
A	TYR404
A	FAD501

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28336141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28398044","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28604669","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29429898","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MZC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MZI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MZK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5X6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5X6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y7A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y7A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---