5WPL

KRas G12V, bound to GppNHp and miniprotein 225-11

Summary for 5WPL

• Entry DOI: 10.2210/pdb5wpl/pdb
• Descriptor: GTPase HRas, Ras-binding peptide, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total)
• Functional Keywords: inhibitor, complex, signaling protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane. Isoform 2: Nucleus: P01112
• Total number of polymer chains: 12
• Total formula weight: 108742.07

Authors

Lee, S.-J.,Shim, S.Y.,McGee, J.H.,Verdine, G.L. (deposition date: 2017-08-05, release date: 2018-01-03, Last modification date: 2018-03-14)

• Primary citation: McGee, J.H.,Shim, S.Y.,Lee, S.J.,Swanson, P.K.,Jiang, S.Y.,Durney, M.A.,Verdine, G.L.; Exceptionally high-affinity Ras binders that remodel its effector domain.; J. Biol. Chem., 293:3265-3280, 2018; PubMed: 29282294; DOI: 10.1074/jbc.M117.816348

Experimental method

X-RAY DIFFRACTION (2.15 Å)