5WPL

KRas G12V, bound to GppNHp and miniprotein 225-11

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
D	0007165	biological_process	signal transduction
D	0016020	cellular_component	membrane
G	0003924	molecular_function	GTPase activity
G	0005525	molecular_function	GTP binding
G	0007165	biological_process	signal transduction
G	0016020	cellular_component	membrane
J	0003924	molecular_function	GTPase activity
J	0005525	molecular_function	GTP binding
J	0007165	biological_process	signal transduction
J	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue GNP A 201

Chain	Residue
A	VAL12
A	ASN116
A	LYS117
A	ASP119
A	LEU120
A	SER145
A	ALA146
A	LYS147
A	MG202
A	HOH304
A	HOH310
A	GLY13
A	HOH324
A	HOH341
J	GLU143
J	HOH314
A	VAL14
A	GLY15
A	LYS16
A	SER17
A	ALA18
A	PHE28
A	GLY60

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 202

Chain	Residue
A	SER17
A	GNP201
A	HOH304
A	HOH324
A	HOH341

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CA A 203

Chain	Residue
A	GLU63
A	HOH343
B	ALA32
I	ASP16

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CA A 204

Chain	Residue
A	GLU63
A	TYR64
I	ASP16
I	GLU19
I	HOH102
I	HOH113

---

site_id	AC5
Number of Residues	5
Details	binding site for residue CA A 205

Chain	Residue
A	GLN25
A	HOH326
A	HOH327
A	HOH340
A	HOH351

---

site_id	AC6
Number of Residues	18
Details	binding site for residue GNP D 201

Chain	Residue
D	VAL12
D	GLY13
D	VAL14
D	GLY15
D	LYS16
D	SER17
D	ALA18
D	PHE28
D	ASN116
D	LYS117
D	ASP119
D	SER145
D	ALA146
D	LYS147
D	MG202
D	HOH316
D	HOH317
D	HOH320

---

site_id	AC7
Number of Residues	5
Details	binding site for residue MG D 202

Chain	Residue
D	SER17
D	GNP201
D	HOH316
D	HOH320
D	HOH326

---

site_id	AC8
Number of Residues	5
Details	binding site for residue CA D 203

Chain	Residue
D	GLU63
E	ALA32
E	HOH101
L	ASP16
L	HOH207

---

site_id	AC9
Number of Residues	18
Details	binding site for residue GNP G 201

Chain	Residue
G	VAL12
G	GLY13
G	VAL14
G	GLY15
G	LYS16
G	SER17
G	ALA18
G	ASN116
G	LYS117
G	ASP119
G	LEU120
G	SER145
G	ALA146
G	LYS147
G	MG202
G	HOH305
G	HOH318
G	HOH324

---

site_id	AD1
Number of Residues	5
Details	binding site for residue MG G 202

Chain	Residue
G	SER17
G	GNP201
G	HOH305
G	HOH324
G	HOH333

---

site_id	AD2
Number of Residues	4
Details	binding site for residue MG G 203

Chain	Residue
C	ASP16
C	HOH107
G	GLU63
H	ALA32

---

site_id	AD3
Number of Residues	6
Details	binding site for residue CA G 204

Chain	Residue
C	GLU19
C	HOH104
C	HOH112
G	GLU63
G	TYR64
C	ASP16

---

site_id	AD4
Number of Residues	18
Details	binding site for residue GNP J 201

Chain	Residue
J	VAL12
J	GLY13
J	VAL14
J	GLY15
J	LYS16
J	SER17
J	ALA18
J	PHE28
J	ASN116
J	LYS117
J	ASP119
J	LEU120
J	SER145
J	ALA146
J	LYS147
J	MG202
J	HOH302
J	HOH317

---

site_id	AD5
Number of Residues	5
Details	binding site for residue MG J 202

Chain	Residue
J	SER17
J	GNP201
J	HOH302
J	HOH317
J	HOH330

---

site_id	AD6
Number of Residues	5
Details	binding site for residue CA J 203

Chain	Residue
F	ASP16
F	HOH112
J	GLU63
K	ALA32
K	HOH106

---

site_id	AD7
Number of Residues	6
Details	binding site for residue CA J 204

Chain	Residue
F	ASP16
F	GLU19
F	HOH104
F	HOH111
J	GLU63
J	TYR64

---

site_id	AD8
Number of Residues	6
Details	binding site for residue CA L 101

Chain	Residue
D	GLU63
D	TYR64
L	ASP16
L	GLU19
L	HOH202
L	HOH206

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Motif: {"description":"Effector region"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	50
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16698776","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N-acetylthreonine; in GTPase HRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"9020151","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9632667","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---