5UXH
Structure of Human POFUT1 in complex with GDP-fucose
Summary for 5UXH
Entry DOI | 10.2210/pdb5uxh/pdb |
Related | 5UX6 |
Descriptor | GDP-fucose protein O-fucosyltransferase 1, GUANOSINE-5'-DIPHOSPHATE-BETA-L-FUCOPYRANOSE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | gdp-fucose, notch signaling, pofut1, t-all, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 85365.18 |
Authors | Xu, X.,McMillan, B.,Blacklow, S.C. (deposition date: 2017-02-22, release date: 2017-04-05, Last modification date: 2023-10-04) |
Primary citation | McMillan, B.J.,Zimmerman, B.,Egan, E.D.,Lofgren, M.,Xu, X.,Hesser, A.,Blacklow, S.C. Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations. Glycobiology, 27:777-786, 2017 Cited by PubMed: 28334865DOI: 10.1093/glycob/cwx020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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