5TWX

Crystal Structure of BRD9 bromodomain

Summary for 5TWX

Entry DOI	10.2210/pdb5twx/pdb
Descriptor	Bromodomain-containing protein 9, N-[6-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)hexyl]-2-(4-{2-[N-(1,1-dioxo-1lambda~6~-thian-4-yl)carbamimidoyl]-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridin-7-yl}-2-methoxyphenoxy)acetamide (3 entities in total)
Functional Keywords	bromodomain, inhibitor, chemical degradation, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	58731.82
Authors	Seo, H.-S.,Dhe-Paganon, S. (deposition date: 2016-11-15, release date: 2017-09-27, Last modification date: 2023-10-04)
Primary citation	Remillard, D.,Buckley, D.L.,Paulk, J.,Brien, G.L.,Sonnett, M.,Seo, H.S.,Dastjerdi, S.,Wuhr, M.,Dhe-Paganon, S.,Armstrong, S.A.,Bradner, J.E. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew. Chem. Int. Ed. Engl., 56:5738-5743, 2017 Cited by PubMed: 28418626 DOI: 10.1002/anie.201611281 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation