5T7F
PI3Kdelta in complex with the inhibitor GS-643624
Summary for 5T7F
Entry DOI | 10.2210/pdb5t7f/pdb |
Related | 5T8I |
Descriptor | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 2,4-bis(azanyl)-6-[[(1~{S})-1-[5-chloranyl-3-(5-fluoranyl-4-methyl-pyridin-3-yl)-4-oxidanylidene-quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile (3 entities in total) |
Functional Keywords | pi3kdelta phosphatidylinositol-3-kinase pi(3)k, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mus musculus (Mouse) |
Cellular location | Cytoplasm : O35904 |
Total number of polymer chains | 2 |
Total formula weight | 216464.96 |
Authors | Somoza, J.R.,Villasenor, A. (deposition date: 2016-09-04, release date: 2016-12-28, Last modification date: 2024-03-06) |
Primary citation | Patel, L.,Chandrasekhar, J.,Evarts, J.,Forseth, K.,Haran, A.,Ip, C.,Kashishian, A.,Kim, M.,Koditek, D.,Koppenol, S.,Lad, L.,Lepist, E.-I.,McGrath, M.E.,Perreault, S.,Puri, K.,Villasenor, A.,Somoza, J.R.,Steiner, B.,Therrien, J.,Trilberg, J.,Phillips, G. The Discovery of GS-9901: A Potent, Selective and Metabolically Stable Inhibitor of PI3Kd To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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