5T7F
PI3Kdelta in complex with the inhibitor GS-643624
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | polymer | 939 | 107766.6 | 2 | UniProt (O35904) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Mus musculus (Mouse) | PtdIns-3-kinase subunit delta,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta,p110delta |
| 2 | A, B | 2,4-bis(azanyl)-6-[[(1~{S})-1-[5-chloranyl-3-(5-fluoranyl-4-methyl-pyridin-3-yl)-4-oxidanylidene-quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile | non-polymer | 465.9 | 2 | Chemie (76C) | |||
| 3 | water | water | 18.0 | 95 | Chemie (HOH) |
Sequence modifications
A, B: 106 - 1044 (UniProt: O35904)
| PDB | External Database | Details |
|---|---|---|
| Gln 508 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 215533.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 931.7 | |
| All* | Total formula weight | 216465.0 |
