5SWK
Crystal structure of p53 epitope-scaffold based on a inhibitor of cysteine proteases in complex with human MDM2
Summary for 5SWK
Entry DOI | 10.2210/pdb5swk/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, De novo protein based on the inhibitor Amoebiasin-1, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | peptidomimetics, biosensor, scaffold, designed, de novo protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 59083.99 |
Authors | Jimenez-Sandoval, P.,Brieba, L.G. (deposition date: 2016-08-08, release date: 2017-10-18, Last modification date: 2023-10-04) |
Primary citation | Jimenez-Sandoval, P.,Madrigal-Carrillo, E.A.,Santamaria-Suarez, H.A.,Maturana, D.,Renteria-Gonzalez, I.,Benitez-Cardoza, C.G.,Torres-Larios, A.,Brieba, L.G. Mimicking a p53-MDM2 interaction based on a stable immunoglobulin-like domain scaffold. Proteins, 86:802-812, 2018 Cited by PubMed: 29696695DOI: 10.1002/prot.25519 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.923 Å) |
Structure validation
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