5O14

Co-crystal structure of a cross-reactive bactericidal human antibody targeting meningococcal vaccine antigen factor H binding protein

Summary for 5O14

• Entry DOI: 10.2210/pdb5o14/pdb
• Descriptor: Factor H binding protein variant 1.1, Fab 1A12 Heavy Chain, Fab 1A12 Light Chain, ... (6 entities in total)
• Functional Keywords: human fab, factor h binding protein, outer membrane, infection, immune system
• Biological source: Neisseria meningitidis serogroup B (strain MC58); More
• Total number of polymer chains: 6
• Total formula weight: 153920.80

Authors

Lopez-Sagaseta, J. (deposition date: 2017-05-18, release date: 2018-02-14, Last modification date: 2024-01-17)

• Primary citation: Lopez-Sagaseta, J.,Beernink, P.T.,Bianchi, F.,Santini, L.,Frigimelica, E.,Lucas, A.H.,Pizza, M.,Bottomley, M.J.; Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp.; Nat Commun, 9:528-528, 2018; PubMed: 29410413; DOI: 10.1038/s41467-018-02827-7

Experimental method

X-RAY DIFFRACTION (2.195 Å)