5O14

Co-crystal structure of a cross-reactive bactericidal human antibody targeting meningococcal vaccine antigen factor H binding protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0009279	cellular_component	cell outer membrane
A	0097691	cellular_component	bacterial extracellular vesicle
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0009279	cellular_component	cell outer membrane
B	0097691	cellular_component	bacterial extracellular vesicle

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue EDO A 301

Chain	Residue
A	LYS165
A	HIS183
A	HOH446
A	HOH456
H	ASN31

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site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 302

Chain	Residue
A	PHE129
A	ARG247
A	HIS248

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site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 303

Chain	Residue
A	THR169
A	ASP171
A	GLN176
A	GLY177
A	ASN178
A	ARG149

---

site_id	AC4
Number of Residues	3
Details	binding site for residue CL C 301

Chain	Residue
C	TRP47
D	THR98
D	PHE99

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site_id	AC5
Number of Residues	3
Details	binding site for residue CL H 301

Chain	Residue
H	TRP47
L	THR98
L	PHE99

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
D	TYR193-HIS199
C	TYR203-HIS209

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	180
Details	Region: {"description":"Domain C","evidences":[{"source":"PubMed","id":"15664958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Important for antibody recognition","evidences":[{"source":"PubMed","id":"15664958","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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