5O14

Co-crystal structure of a cross-reactive bactericidal human antibody targeting meningococcal vaccine antigen factor H binding protein

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Factor H binding protein variant 1.1	polymer	257	27699.9	2	UniProt (Q9JXV4) Pfam (PF20937) Pfam (PF08794)	Neisseria meningitidis serogroup B (strain MC58)
2	C, F (C, H)	Fab 1A12 Heavy Chain	polymer	235	25461.6	2		Homo sapiens
3	D, E (D, L)	Fab 1A12 Light Chain	polymer	217	23670.3	2		Homo sapiens
4	G, H, I (A)	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
5	J, K (C, H)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
6	L, M, N, O, P... (A, B, C, D, L...)	water	water		18.0	917	Chemie (HOH)

Sequence modifications

A, B: 8 - 255 (UniProt: Q9JXV4)

PDB	External Database	Details
Met 7	-	initiating methionine
Leu 256	-	expression tag
Glu 257	-	expression tag
His 258	-	expression tag
His 259	-	expression tag
His 260	-	expression tag
His 261	-	expression tag
His 262	-	expression tag
His 263	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	153663.7
Non-Polymers*	Number of molecules	5
	Total formula weight	257.1
All*	Total formula weight	153920.8

*Water molecules are not included.