5NX2
Crystal structure of thermostabilised full-length GLP-1R in complex with a truncated peptide agonist at 3.7 A resolution
Summary for 5NX2
Entry DOI | 10.2210/pdb5nx2/pdb |
Descriptor | Glucagon-like peptide 1 receptor, truncated peptide agonist, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | 7tm, gpcr, signalling protein, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 52088.24 |
Authors | Rappas, M.,Jazayeri, A.,Brown, A.J.H.,Kean, J.,Errey, J.C.,Robertson, N.,Fiez-Vandal, C.,Andrews, S.P.,Congreve, M.,Bortolato, A.,Mason, J.S.,Baig, A.H.,Teobald, I.,Dore, A.S.,Weir, M.,Cooke, R.M.,Marshall, F.H. (deposition date: 2017-05-09, release date: 2017-06-14, Last modification date: 2024-01-17) |
Primary citation | Jazayeri, A.,Rappas, M.,Brown, A.J.H.,Kean, J.,Errey, J.C.,Robertson, N.J.,Fiez-Vandal, C.,Andrews, S.P.,Congreve, M.,Bortolato, A.,Mason, J.S.,Baig, A.H.,Teobald, I.,Dore, A.S.,Weir, M.,Cooke, R.M.,Marshall, F.H. Crystal structure of the GLP-1 receptor bound to a peptide agonist. Nature, 546:254-258, 2017 Cited by PubMed: 28562585DOI: 10.1038/nature22800 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.7 Å) |
Structure validation
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