5KQV
Insulin receptor ectodomain construct comprising domains L1,CR,L2, FnIII-1 and alphaCT peptide in complex with bovine insulin and FAB 83-14 (REVISED STRUCTURE)
Replaces: 3W14Summary for 5KQV
Entry DOI | 10.2210/pdb5kqv/pdb |
Related | 4ZXB |
Descriptor | Insulin, MONOCLONAL ANTIBODY FAB 83-14 - HEAVY CHAIN, MONOCLONAL ANTIBODY FAB 83-14 - LIGHT CHAIN, ... (7 entities in total) |
Functional Keywords | cell surface receptor/immune system, insulin receptor, ir ectodomain, ct peptide, hormone-hormone receptor-immune system complex, hormone/hormone receptor/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 10 |
Total formula weight | 247027.06 |
Authors | Lawrence, M.C.,Smith, B.J.,Croll, T.I. (deposition date: 2016-07-06, release date: 2017-07-19, Last modification date: 2023-10-04) |
Primary citation | Menting, J.G.,Whittaker, J.,Margetts, M.B.,Whittaker, L.J.,Kong, G.K.,Smith, B.J.,Watson, C.J.,Zakova, L.,Kletvikova, E.,Jiracek, J.,Chan, S.J.,Steiner, D.F.,Dodson, G.G.,Brzozowski, A.M.,Weiss, M.A.,Ward, C.W.,Lawrence, M.C. How insulin engages its primary binding site on the insulin receptor. Nature, 493:241-245, 2013 Cited by PubMed: 23302862DOI: 10.1038/nature11781 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.4 Å) |
Structure validation
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