5IES
Crystal structure of VRC01c-HuGL2 Fab from an HIV-1 naive donor in complex with with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.16 A
Summary for 5IES
Entry DOI | 10.2210/pdb5ies/pdb |
Related | 5IF0 5IFA |
Descriptor | VRC01cHuGL2 Fab heavy chain, VRC01cHuGL2 Fab light chain, Germline-targeting HIV-1 gp120 engineered outer domain eOD-GT8, ... (6 entities in total) |
Functional Keywords | hiv-1 gp120, engineered outer domain (eod), germline targeting, cd4 binding site, vrc01-class naive human germline antibody, immune system, viral-protein complex, immune system-viral protein complex, immune system- viral protein complex, immune system/ viral protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 68038.93 |
Authors | Sarkar, A.,Wilson, I.A. (deposition date: 2016-02-25, release date: 2016-04-06, Last modification date: 2023-09-27) |
Primary citation | Jardine, J.G.,Kulp, D.W.,Havenar-Daughton, C.,Sarkar, A.,Briney, B.,Sok, D.,Sesterhenn, F.,Ereno-Orbea, J.,Kalyuzhniy, O.,Deresa, I.,Hu, X.,Spencer, S.,Jones, M.,Georgeson, E.,Adachi, Y.,Kubitz, M.,deCamp, A.C.,Julien, J.P.,Wilson, I.A.,Burton, D.R.,Crotty, S.,Schief, W.R. HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen. Science, 351:1458-1463, 2016 Cited by PubMed: 27013733DOI: 10.1126/science.aad9195 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.16 Å) |
Structure validation
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