5ICV

Crystal structure of human NatF (hNaa60) bound to a bisubstrate analogue

Summary for 5ICV

Entry DOI	10.2210/pdb5icv/pdb
Descriptor	N-alpha-acetyltransferase 60, MET-LYS-ALA-VAL-LIG, [5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)furan-2-yl]methyl (3R)-4-{[3-({(E)-2-[(2,2-dihydroxyethyl)sulfanyl]ethenyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate, ... (4 entities in total)
Functional Keywords	transferase, acetylation, gnat, nat
Biological source	Homo sapiens (Human) More
Cellular location	Golgi apparatus membrane : Q9H7X0
Total number of polymer chains	4
Total formula weight	43618.96
Authors	Stove, S.I.,Magin, R.S.,Marmorstein, R.,Arnesen, T. (deposition date: 2016-02-23, release date: 2016-06-22, Last modification date: 2024-01-10)
Primary citation	Stve, S.I.,Magin, R.S.,Foyn, H.,Haug, B.E.,Marmorstein, R.,Arnesen, T. Crystal Structure of the Golgi-Associated Human N alpha-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation. Structure, 24:1044-1056, 2016 Cited by PubMed: 27320834 DOI: 10.1016/j.str.2016.04.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation