5ICV

Crystal structure of human NatF (hNaa60) bound to a bisubstrate analogue

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0004596	molecular_function	protein-N-terminal amino-acid acetyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	36
Details	binding site for Di-peptide 1XE C 101 and MET C 1

Chain	Residue
A	PHE34
A	HIS110
A	GLY111
A	ILE112
A	GLY113
A	SER114
A	HIS138
A	ASN143
A	THR145
A	PHE149
A	TYR150
A	ILE36
A	ASN152
A	ARG153
A	TYR165
A	HOH222
A	HOH223
A	HOH224
A	HOH267
B	ASN152
B	ARG153
C	LYS2
A	LEU99
C	ALA3
C	HOH201
C	HOH202
C	HOH203
C	HOH205
D	1XE101
D	HOH206
A	SER100
A	LEU101
A	GLY102
A	VAL103
A	ARG108
A	LYS109

---

site_id	AC2
Number of Residues	36
Details	binding site for Di-peptide 1XE D 101 and MET D 1

Chain	Residue
A	ASN152
A	ARG153
B	PHE34
B	ILE36
B	LEU99
B	SER100
B	LEU101
B	GLY102
B	VAL103
B	ARG108
B	LYS109
B	HIS110
B	GLY111
B	ILE112
B	GLY113
B	SER114
B	HIS138
B	ASN143
B	THR145
B	PHE149
B	TYR150
B	ASN152
B	ARG153
B	TYR165
B	HOH237
B	HOH259
C	1XE101
D	LYS2
D	ALA3
D	HOH201
D	HOH203
D	HOH204
D	HOH205
D	HOH206
D	HOH207
D	HOH208

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	338
Details	Domain: {"description":"N-acetyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00532","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	Region: {"description":"Required for homodimerization","evidences":[{"source":"PubMed","id":"27320834","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"27320834","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27550639","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27320834","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ICV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5ICW","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27320834","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27550639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5HGZ","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5HH0","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5HH1","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5ICV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5ICW","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Required to position thioacetyl group","evidences":[{"source":"PubMed","id":"27550639","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"PubMed","id":"21981917","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"PubMed","id":"21981917","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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