5ICV
Crystal structure of human NatF (hNaa60) bound to a bisubstrate analogue
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004596 | molecular_function | peptide alpha-N-acetyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0004596 | molecular_function | peptide alpha-N-acetyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | binding site for Di-peptide 1XE C 101 and MET C 1 |
| Chain | Residue |
| A | PHE34 |
| A | HIS110 |
| A | GLY111 |
| A | ILE112 |
| A | GLY113 |
| A | SER114 |
| A | HIS138 |
| A | ASN143 |
| A | THR145 |
| A | PHE149 |
| A | TYR150 |
| A | ILE36 |
| A | ASN152 |
| A | ARG153 |
| A | TYR165 |
| A | HOH222 |
| A | HOH223 |
| A | HOH224 |
| A | HOH267 |
| B | ASN152 |
| B | ARG153 |
| C | LYS2 |
| A | LEU99 |
| C | ALA3 |
| C | HOH201 |
| C | HOH202 |
| C | HOH203 |
| C | HOH205 |
| D | 1XE101 |
| D | HOH206 |
| A | SER100 |
| A | LEU101 |
| A | GLY102 |
| A | VAL103 |
| A | ARG108 |
| A | LYS109 |
| site_id | AC2 |
| Number of Residues | 36 |
| Details | binding site for Di-peptide 1XE D 101 and MET D 1 |
| Chain | Residue |
| A | ASN152 |
| A | ARG153 |
| B | PHE34 |
| B | ILE36 |
| B | LEU99 |
| B | SER100 |
| B | LEU101 |
| B | GLY102 |
| B | VAL103 |
| B | ARG108 |
| B | LYS109 |
| B | HIS110 |
| B | GLY111 |
| B | ILE112 |
| B | GLY113 |
| B | SER114 |
| B | HIS138 |
| B | ASN143 |
| B | THR145 |
| B | PHE149 |
| B | TYR150 |
| B | ASN152 |
| B | ARG153 |
| B | TYR165 |
| B | HOH237 |
| B | HOH259 |
| C | 1XE101 |
| D | LYS2 |
| D | ALA3 |
| D | HOH201 |
| D | HOH203 |
| D | HOH204 |
| D | HOH205 |
| D | HOH206 |
| D | HOH207 |
| D | HOH208 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:27320834, ECO:0000269|PubMed:27550639 |
| Chain | Residue | Details |
| A | TYR97 | |
| A | HIS138 | |
| B | TYR97 | |
| B | HIS138 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27320834, ECO:0000312|PDB:5ICV, ECO:0000312|PDB:5ICW |
| Chain | Residue | Details |
| B | LEU99 | |
| B | TYR165 | |
| B | TYR38 | |
| A | TYR38 | |
| A | LEU99 | |
| A | TYR165 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27320834, ECO:0000269|PubMed:27550639, ECO:0000312|PDB:5HGZ, ECO:0000312|PDB:5HH0, ECO:0000312|PDB:5HH1, ECO:0000312|PDB:5ICV, ECO:0000312|PDB:5ICW |
| Chain | Residue | Details |
| A | ASN143 | |
| A | TYR150 | |
| B | LEU101 | |
| B | LYS109 | |
| B | ASN143 | |
| B | TYR150 | |
| A | LEU101 | |
| A | LYS109 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Required to position thioacetyl group => ECO:0000269|PubMed:27550639 |
| Chain | Residue | Details |
| B | PHE34 | |
| A | PHE34 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:21981917 |
| Chain | Residue | Details |
| A | LYS156 | |
| B | LYS79 | |
| B | LYS105 | |
| B | LYS156 | |
| A | LYS79 | |
| A | LYS105 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000305|PubMed:21981917 |
| Chain | Residue | Details |
| B | LYS109 | |
| B | LYS121 | |
| A | LYS109 | |
| A | LYS121 |
