5HJ3

Crystal structure of host-primed Ebola virus GP, GPcl.

Summary for 5HJ3

• Entry DOI: 10.2210/pdb5hj3/pdb
• Descriptor: Envelope glycoprotein, KZ52 Antibody Fragment, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: ebola virus, eov, ebolavirus, gp, glycoprotein, gpcl, cleaved, primed, proteolytically, receptor binding pocket, crest, trough, mr72, kz52, broadly neutralizing, viral protein-immune system complex, viral protein/immune system
• Biological source: Ebola virus sp.; More
• Cellular location: GP2: Virion membrane ; Single-pass type I membrane protein . GP1: Virion membrane ; Peripheral membrane protein. GP2-delta: Secreted : Q05320 P87666
• Total number of polymer chains: 16
• Total formula weight: 336368.72

Authors

Bornholdt, Z.A.,Fusco, M.L.,Saphire, E.O. (deposition date: 2016-01-12, release date: 2016-03-09, Last modification date: 2020-07-29)

• Primary citation: Bornholdt, Z.A.,Ndungo, E.,Fusco, M.L.,Bale, S.,Flyak, A.I.,Crowe, J.E.,Chandran, K.,Saphire, E.O.; Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies.; Mbio, 7:e02154-e02115, 2016; PubMed: 26908579; DOI: 10.1128/mBio.02154-15

Experimental method

X-RAY DIFFRACTION (3.3 Å)