5DG5
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET IN COMPLEX WITH ALTIRATINIB ANALOG DP-4157
Summary for 5DG5
Entry DOI | 10.2210/pdb5dg5/pdb |
Descriptor | Hepatocyte growth factor receptor, N-(2,5-difluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxam ide (3 entities in total) |
Functional Keywords | tyrosine kinase domain, hepatocyte growth factor receptor c-met, c-met, altiratinib analog, dp-4157, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581 |
Total number of polymer chains | 2 |
Total formula weight | 72996.19 |
Authors | Smith, B.D.,Kaufman, M.D.,Leary, C.B.,Turner, B.A.,Wise, S.A.,Ahn, Y.M.,Booth, R.J.,Caldwell, T.M.,Ensinger, C.L.,Hood, M.M.,Lu, W.-P.,Patt, T.W.,Patt, W.C.,Rutkoski, T.J.,Samarakoon, T.,Telikepalli, H.,Vogeti, L.,Vogeti, S.,Yates, K.M.,Chun, L.,Stewart, L.J.,Clare, M.,Flynn, D.L. (deposition date: 2015-08-27, release date: 2016-08-31, Last modification date: 2023-09-27) |
Primary citation | Smith, B.D.,Kaufman, M.D.,Leary, C.B.,Turner, B.A.,Wise, S.C.,Ahn, Y.M.,Booth, R.J.,Caldwell, T.M.,Ensinger, C.L.,Hood, M.M.,Lu, W.P.,Patt, T.W.,Patt, W.C.,Rutkoski, T.J.,Samarakoon, T.,Telikepalli, H.,Vogeti, L.,Vogeti, S.,Yates, K.M.,Chun, L.,Stewart, L.J.,Clare, M.,Flynn, D.L. Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2. Mol.Cancer Ther., 14:2023-2034, 2015 Cited by PubMed: 26285778DOI: 10.1158/1535-7163.MCT-14-1105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report