5DB3
Menin in complex with MI-574
Summary for 5DB3
Entry DOI | 10.2210/pdb5db3/pdb |
Related | 5DB0 5DB1 5DB2 |
Descriptor | Menin, DIMETHYL SULFOXIDE, TETRAETHYLENE GLYCOL, ... (7 entities in total) |
Functional Keywords | protein binding, protein binding-inhibitor complex, protein binding/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 56278.10 |
Authors | Pollock, J.,Borkin, D.,Cierpicki, T.,Grembecka, J. (deposition date: 2015-08-20, release date: 2016-03-30, Last modification date: 2024-03-06) |
Primary citation | Borkin, D.,Pollock, J.,Kempinska, K.,Purohit, T.,Li, X.,Wen, B.,Zhao, T.,Miao, H.,Shukla, S.,He, M.,Sun, D.,Cierpicki, T.,Grembecka, J. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J.Med.Chem., 59:892-913, 2016 Cited by PubMed: 26744767DOI: 10.1021/acs.jmedchem.5b01305 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.71 Å) |
Structure validation
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