5CZV
Crystal structure of Notch3 NRR in complex with 20350 Fab
Summary for 5CZV
Entry DOI | 10.2210/pdb5czv/pdb |
Related | 5CZX |
Descriptor | Neurogenic locus notch homolog protein 3, Fab 20350 heavy chain, Fab 20350 light chain, ... (6 entities in total) |
Functional Keywords | antibody, notch3, oncology, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 77789.93 |
Authors | Hu, T.,Fryer, C.,Chopra, R.,Clark, K. (deposition date: 2015-08-01, release date: 2016-06-01, Last modification date: 2023-09-27) |
Primary citation | Bernasconi-Elias, P.,Hu, T.,Jenkins, D.,Firestone, B.,Gans, S.,Kurth, E.,Capodieci, P.,Deplazes-Lauber, J.,Petropoulos, K.,Thiel, P.,Ponsel, D.,Hee Choi, S.,LeMotte, P.,London, A.,Goetcshkes, M.,Nolin, E.,Jones, M.D.,Slocum, K.,Kluk, M.J.,Weinstock, D.M.,Christodoulou, A.,Weinberg, O.,Jaehrling, J.,Ettenberg, S.A.,Buckler, A.,Blacklow, S.C.,Aster, J.C.,Fryer, C.J. Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene, 35:6077-6086, 2016 Cited by PubMed: 27157619DOI: 10.1038/onc.2016.133 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.19 Å) |
Structure validation
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