5CZV
Crystal structure of Notch3 NRR in complex with 20350 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Neurogenic locus notch homolog protein 3 | polymer | 271 | 30096.6 | 1 | UniProt (Q9UM47) Pfam (PF00066) Pfam (PF06816) Pfam (PF07684) | Homo sapiens (Human) | Notch 3 |
| 2 | B (H) | Fab 20350 heavy chain | polymer | 223 | 23794.7 | 1 | Homo sapiens (Human) | IgG20350 heavy chain, NVP-LMW976 heavy chain | |
| 3 | C (L) | Fab 20350 light chain | polymer | 214 | 23557.2 | 1 | Homo sapiens (Human) | IgG20350 light chain, NVP-LMW976 light chain | |
| 4 | D, E, F (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 5 | G (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | H, I, J (A, H, L) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A: 1378 - 1640 (UniProt: Q9UM47)
| PDB | External Database | Details |
|---|---|---|
| Gly 1641 | - | expression tag |
| Ser 1642 | - | expression tag |
| His 1643 | - | expression tag |
| His 1644 | - | expression tag |
| His 1645 | - | expression tag |
| His 1646 | - | expression tag |
| His 1647 | - | expression tag |
| His 1648 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 77448.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 341.4 | |
| All* | Total formula weight | 77789.9 |
