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5CZX

Crystal structure of Notch3 NRR in complex with 20358 Fab

Summary for 5CZX
Entry DOI10.2210/pdb5czx/pdb
Related5CZV
DescriptorNeurogenic locus notch homolog protein 3, 20358 Fab heavy chain, 20358 Fab light chain, ... (8 entities in total)
Functional Keywordsantibody, notch3, oncology, immune system
Biological sourceHomo sapiens (Human)
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Total number of polymer chains6
Total formula weight156614.95
Authors
Hu, T.,Fryer, C.,Chopra, R.,Clark, K. (deposition date: 2015-08-01, release date: 2016-06-01, Last modification date: 2023-09-27)
Primary citationBernasconi-Elias, P.,Hu, T.,Jenkins, D.,Firestone, B.,Gans, S.,Kurth, E.,Capodieci, P.,Deplazes-Lauber, J.,Petropoulos, K.,Thiel, P.,Ponsel, D.,Hee Choi, S.,LeMotte, P.,London, A.,Goetcshkes, M.,Nolin, E.,Jones, M.D.,Slocum, K.,Kluk, M.J.,Weinstock, D.M.,Christodoulou, A.,Weinberg, O.,Jaehrling, J.,Ettenberg, S.A.,Buckler, A.,Blacklow, S.C.,Aster, J.C.,Fryer, C.J.
Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.
Oncogene, 35:6077-6086, 2016
Cited by
PubMed: 27157619
DOI: 10.1038/onc.2016.133
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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