5CZX
Crystal structure of Notch3 NRR in complex with 20358 Fab
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Neurogenic locus notch homolog protein 3 | polymer | 271 | 30096.6 | 2 | UniProt (Q9UM47) Pfam (PF00066) Pfam (PF06816) Pfam (PF07684) In PDB | Homo sapiens (Human) | Notch 3 |
2 | C, H | 20358 Fab heavy chain | polymer | 226 | 24118.0 | 2 | Homo sapiens (Human) | IgG20358 heavy chain, NVP-LMW985 heavy chain | |
3 | D, L | 20358 Fab light chain | polymer | 214 | 23387.9 | 2 | Homo sapiens (Human) | IgG20358 light chain, NVP-LMW985 light chain | |
4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
5 | A, B | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) | |||
6 | L, A, B, C, D... | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
7 | C, H, L | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
8 | water | water | 18.0 | 850 | Chemie (HOH) |
Sequence modifications
A, B: 1378 - 1640 (UniProt: Q9UM47)
PDB | External Database | Details |
---|---|---|
Gly 1641 | - | expression tag |
Ser 1642 | - | expression tag |
His 1643 | - | expression tag |
His 1644 | - | expression tag |
His 1645 | - | expression tag |
His 1646 | - | expression tag |
His 1647 | - | expression tag |
His 1648 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 155205.0 | |
Non-Polymers* | Number of molecules | 21 |
Total formula weight | 1409.9 | |
All* | Total formula weight | 156615.0 |