5C91
NEDD4 HECT with covalently bound indole-based inhibitor
Summary for 5C91
Entry DOI | 10.2210/pdb5c91/pdb |
Related | 2XBB 2XBF |
Descriptor | E3 ubiquitin-protein ligase NEDD4, methyl (2E)-4-{[(5-methoxy-1,2-dimethyl-1H-indol-3-yl)carbonyl]amino}but-2-enoate (3 entities in total) |
Functional Keywords | nedd4, hect, ligase, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P46934 |
Total number of polymer chains | 1 |
Total formula weight | 45055.38 |
Authors | Span, I.,Smith, A.T.,Kathman, S.,Statsyuk, A.V.,Rosenzweig, A.C. (deposition date: 2015-06-26, release date: 2015-09-30, Last modification date: 2024-10-09) |
Primary citation | Kathman, S.G.,Span, I.,Smith, A.T.,Xu, Z.,Zhan, J.,Rosenzweig, A.C.,Statsyuk, A.V. A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism. J. Am. Chem. Soc., 137:12442-12445, 2015 Cited by PubMed: 26371805DOI: 10.1021/jacs.5b06839 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
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