5BQC
Crystal structure of Norrin in complex with the cysteine-rich domain of Frizzled 4 and sucrose octasulfate
Summary for 5BQC
Entry DOI | 10.2210/pdb5bqc/pdb |
Related | 5BPB 5BPQ 5BPU 5BQ8 5BQB |
Related PRD ID | PRD_900013 |
Descriptor | Frizzled-4, Norrin, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | wnt signalling pathway, norrie disease protein, glycoprotein, g protein coupled receptor, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 31745.16 |
Authors | Chang, T.-H.,Hsieh, F.-L.,Zebisch, M.,Harlos, K.,Jones, E.Y. (deposition date: 2015-05-28, release date: 2015-07-01, Last modification date: 2024-01-10) |
Primary citation | Chang, T.H.,Hsieh, F.L.,Zebisch, M.,Harlos, K.,Elegheert, J.,Jones, E.Y. Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan. Elife, 4:e06554-, 2015 Cited by PubMed: 26158506DOI: 10.7554/eLife.06554 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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