5BQC
Crystal structure of Norrin in complex with the cysteine-rich domain of Frizzled 4 and sucrose octasulfate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | Frizzled-4 | polymer | 149 | 16705.2 | 1 | UniProt (Q9ULV1) Pfam (PF01392) In PDB | Homo sapiens (Human) | hFz4,FzE4 |
2 | A | Norrin | polymer | 122 | 13614.7 | 1 | UniProt (Q00604) Pfam (PF00007) In PDB | Homo sapiens (Human) | Norrie disease protein,X-linked exudative vitreoretinopathy 2 protein |
3 | C | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose | branched | 982.8 | 1 | In PDB BIRD (PRD_900013) | sucrose octasulfate | ||
4 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
B: 42 - 179 (UniProt: Q9ULV1)
A: 25 - 133 (UniProt: Q00604)
PDB | External Database | Details |
---|---|---|
Asp 39 | - | expression tag |
Thr 40 | - | expression tag |
Gly 41 | - | expression tag |
Gly 180 | - | expression tag |
Thr 181 | - | expression tag |
Leu 182 | - | expression tag |
Glu 183 | - | expression tag |
Val 184 | - | expression tag |
Leu 185 | - | expression tag |
Phe 186 | - | expression tag |
Gln 187 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 22 | - | expression tag |
Pro 23 | - | expression tag |
Gly 24 | - | expression tag |
Gly 134 | - | expression tag |
Thr 135 | - | expression tag |
Glu 136 | - | expression tag |
Thr 137 | - | expression tag |
Ser 138 | - | expression tag |
Gln 139 | - | expression tag |
Val 140 | - | expression tag |
Ala 141 | - | expression tag |
Pro 142 | - | expression tag |
Ala 143 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 30319.9 | |
Branched | Number of molecules | 1 |
Total formula weight | 982.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 442.4 | |
All* | Total formula weight | 31745.2 |