4ZZN

Human ERK2 in complex with an inhibitor

Summary for 4ZZN

Entry DOI	10.2210/pdb4zzn/pdb
Related	4ZZM 4ZZO
Descriptor	MITOGEN-ACTIVATED PROTEIN KINASE 1, SULFATE ION, 2-[[5-chloranyl-2-(oxan-4-ylamino)pyridin-4-yl]amino]-N-methyl-benzamide, ... (4 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm, cytoskeleton, spindle : P28482
Total number of polymer chains	1
Total formula weight	41248.86
Authors	Ward, R.A.,Colclough, N.,Challinor, M.,Debreczeni, J.E.,Eckersley, K.,Fairley, G.,Feron, L.,Flemington, V.,Graham, M.A.,Greenwood, R.,Hopcroft, P.,Howard, T.D.,James, M.,Jones, C.D.,Jones, C.R.,Renshaw, J.,Roberts, K.,Snow, L.,Tonge, M.,Yeung, K. (deposition date: 2015-04-10, release date: 2015-05-27, Last modification date: 2015-08-26)
Primary citation	Ward, R.A.,Colclough, N.,Challinor, M.,Debreczeni, J.,Eckersley, K.,Fairley, G.,Feron, L.,Flemington, V.,Graham, M.A.,Greenwood, R.,Hopcroft, P.,Howard, T.D.,James, M.,Jones, C.D.,Jones, C.R.,Renshaw, J.,Roberts, K.,Snow, L.,Tonge, M.,Yeung, K. Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of Erk1/2. J.Med.Chem., 58:4790-, 2015 Cited by PubMed: 25977981 DOI: 10.1021/ACS.JMEDCHEM.5B00466 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.33 Å)

Structure validation