4ZYC

Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode: Hdm2 (MDM2) complexed with cpd5

4ZYC の概要

• エントリーDOI: 10.2210/pdb4zyc/pdb
• 関連するPDBエントリー: 4DIJ 4OQ3
• 分子名称: E3 ubiquitin-protein ligase Mdm2, (S)-2-(2-((2H-tetrazol-5-yl)methoxy)-4-methylphenyl)-1-(4-chlorophenyl)-6,7-diethoxy-1,2-dihydroisoquinolin-3(4H)-one, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: ppi with p53, inhibitor complex, ligase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus, nucleoplasm: Q00987
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35214.11

構造登録者

Kallen, J. (登録日: 2015-05-21, 公開日: 2015-07-22, 最終更新日: 2024-01-10)

• 主引用文献: Gessier, F.,Kallen, J.,Jacoby, E.,Chene, P.,Stachyra-Valat, T.,Ruetz, S.,Jeay, S.,Holzer, P.,Masuya, K.,Furet, P.; Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode.; Bioorg.Med.Chem.Lett., 25:3621-3625, 2015; PubMed: 26141769; DOI: 10.1016/j.bmcl.2015.06.058

実験手法

X-RAY DIFFRACTION (1.95 Å)