4ZVQ

Caspase-7 Variant 2 (V2) with reprogrammed substrate specificity due to Y230V/W232M/Q276C substitutions bound to VEID inhibitor.

Summary for 4ZVQ

Entry DOI	10.2210/pdb4zvq/pdb
Related	1F1J 3EDR 4ZVO 4ZVP 4ZVR 4ZVS 4ZVT 4ZVU
Related PRD ID	PRD_000976
Descriptor	Caspase-7, Peptide ACE-VAL-GLU-ILE-ASA, ... (4 entities in total)
Functional Keywords	directed evolution, protease, peptide inhibitor, designed active site specificity, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	71507.01
Authors	Hill, M.E.,MacPherson, D.J.,Hardy, J.A. (deposition date: 2015-05-18, release date: 2016-04-20, Last modification date: 2023-11-15)
Primary citation	Hill, M.E.,MacPherson, D.J.,Wu, P.,Julien, O.,Wells, J.A.,Hardy, J.A. Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition. Acs Chem.Biol., 11:1603-1612, 2016 Cited by PubMed: 27032039 DOI: 10.1021/acschembio.5b00971 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation