4ZLP

Crystal Structure of Notch3 Negative Regulatory Region

4ZLP の概要

• エントリーDOI: 10.2210/pdb4zlp/pdb
• 分子名称: Neurogenic locus notch homolog protein 3, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (7 entities in total)
• 機能のキーワード: notch, mutation, disease, autoinhibiton, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61797.97

構造登録者

Xu, X.,Blacklow, S.C. (登録日: 2015-05-01, 公開日: 2015-08-19, 最終更新日: 2020-07-29)

• 主引用文献: Xu, X.,Choi, S.H.,Hu, T.,Tiyanont, K.,Habets, R.,Groot, A.J.,Vooijs, M.,Aster, J.C.,Chopra, R.,Fryer, C.,Blacklow, S.C.; Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region.; Structure, 23:1227-1235, 2015; PubMed: 26051713; DOI: 10.1016/j.str.2015.05.001

実験手法

X-RAY DIFFRACTION (2.479 Å)