4ZL4
Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-842)
Summary for 4ZL4
Entry DOI | 10.2210/pdb4zl4/pdb |
Related PRD ID | PRD_002168 |
Descriptor | Aspartic protease PM5, N-[(benzyloxy)carbonyl]-O-carbamimidamido-L-homoseryl-N-{(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl}-L-valinamide, SULFATE ION, ... (6 entities in total) |
Functional Keywords | malaria, inhibitor, aspartyl protease, pexel, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Plasmodium vivax |
Total number of polymer chains | 2 |
Total formula weight | 103740.46 |
Authors | Czabotar, P.E.,Hodder, A.N.,Smith, B.J.,Sleebs, B.E.,Gazdic, M.,Boddey, J.A.,Cowman, A.F. (deposition date: 2015-05-01, release date: 2015-07-15, Last modification date: 2023-09-27) |
Primary citation | Hodder, A.N.,Sleebs, B.E.,Czabotar, P.E.,Gazdik, M.,Xu, Y.,O'Neill, M.T.,Lopaticki, S.,Nebl, T.,Triglia, T.,Smith, B.J.,Lowes, K.,Boddey, J.A.,Cowman, A.F. Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes. Nat.Struct.Mol.Biol., 22:590-596, 2015 Cited by PubMed: 26214367DOI: 10.1038/nsmb.3061 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.37 Å) |
Structure validation
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