4ZJR

RORgamma in complex with inverse agonist 48

Summary for 4ZJR

Entry DOI	10.2210/pdb4zjr/pdb
Descriptor	Nuclear receptor ROR-gamma, 6-chloro-4'-[(2-chloro-6-fluorobenzoyl)(methyl)amino]-3'-(2,2,2-trifluoroethoxy)biphenyl-3-carboxamide (3 entities in total)
Functional Keywords	rorgamma ligand binding domain, inverse agonist, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P51449
Total number of polymer chains	4
Total formula weight	106702.06
Authors	Marcotte, D.J. (deposition date: 2015-04-29, release date: 2015-06-17, Last modification date: 2023-09-27)
Primary citation	Chao, J.,Enyedy, I.,Van Vloten, K.,Marcotte, D.,Guertin, K.,Hutchings, R.,Powell, N.,Jones, H.,Bohnert, T.,Peng, C.C.,Silvian, L.,Hong, V.S.,Little, K.,Banerjee, D.,Peng, L.,Taveras, A.,Viney, J.L.,Fontenot, J. Discovery of biaryl carboxylamides as potent ROR gamma inverse agonists. Bioorg.Med.Chem.Lett., 25:2991-2997, 2015 Cited by PubMed: 26048806 DOI: 10.1016/j.bmcl.2015.05.026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.702 Å)

Structure validation