4Z8D

Antibacterial FabH Inhibitors with Validated Mode of Action in Haemophilus Influenzae by in vitro resistance mutation mapping

Summary for 4Z8D

• Entry DOI: 10.2210/pdb4z8d/pdb
• Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 3, trans-4-[({[(2-chlorobenzyl)oxy]carbonyl}amino)methyl]cyclohexanecarboxylic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: beta-ketoacyl-(acyl-carrier-protein) synthase iii, carbamate, structure based drug design, fatty acid biosynthesis, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Escherichia coli O157:H7
• Cellular location: Cytoplasm : P0A6R2
• Total number of polymer chains: 2
• Total formula weight: 67937.75

Authors

Lahiri, S.D. (deposition date: 2015-04-08, release date: 2016-05-04, Last modification date: 2024-03-06)

• Primary citation: McKinney, D.C.,Eyermann, C.J.,Gu, R.F.,Hu, J.,Kazmirski, S.L.,Lahiri, S.D.,McKenzie, A.R.,Shapiro, A.B.,Breault, G.; Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping.; Acs Infect Dis., 2:456-464, 2016; PubMed: 27626097; DOI: 10.1021/acsinfecdis.6b00053

Experimental method

X-RAY DIFFRACTION (2 Å)