4Z8D
Antibacterial FabH Inhibitors with Validated Mode of Action in Haemophilus Influenzae by in vitro resistance mutation mapping
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0030497 | biological_process | fatty acid elongation |
| A | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0030497 | biological_process | fatty acid elongation |
| B | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue 4LB A 401 |
| Chain | Residue |
| A | ARG36 |
| A | PHE304 |
| A | HOH531 |
| A | HOH554 |
| A | HOH662 |
| B | THR18 |
| B | ALA20 |
| A | GLY209 |
| A | VAL212 |
| A | PHE213 |
| A | ALA216 |
| A | ALA246 |
| A | ARG249 |
| A | ILE250 |
| A | ASN274 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | THR177 |
| A | LEU179 |
| A | HOH501 |
| A | HOH536 |
| B | PRO104 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue 4LB B 401 |
| Chain | Residue |
| B | TRP32 |
| B | ARG36 |
| B | ILE156 |
| B | MET207 |
| B | GLY209 |
| B | ASN210 |
| B | VAL212 |
| B | PHE213 |
| B | ALA216 |
| B | ALA246 |
| B | ILE250 |
| B | ASN274 |
| B | PHE304 |
| B | HOH501 |
| B | HOH537 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| A | LYS132 |
| B | SER202 |
| B | ILE203 |
| B | HIS204 |
| B | HOH531 |
| B | HOH553 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Region: {"description":"ACP-binding","evidences":[{"source":"HAMAP-Rule","id":"MF_01815","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01815","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
