4Z7M

Novel Inhibitors of Bacterial Methionine Aminopeptidase with Broad-Spectrum Biochemical Activity

Summary for 4Z7M

• Entry DOI: 10.2210/pdb4z7m/pdb
• Descriptor: Methionine aminopeptidase, MANGANESE (II) ION, N~2~-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide, ... (4 entities in total)
• Functional Keywords: antibacterial, methionine aminopeptidase, azepinone, structure-based design, drug discovery, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 58983.70

Authors

Rose, J.A.,Lahiri, S.D.,McKinney, D.C.,Albert, R.,Morningstar, M.,Shapiro, A.B.,Fisher, S.F.,Fleming, P.R. (deposition date: 2015-04-07, release date: 2016-04-13, Last modification date: 2024-03-06)

• Primary citation: Rose, J.A.,Lahiri, S.D.,McKinney, D.C.,Albert, R.,Morningstar, M.,Shapiro, A.B.,Fisher, S.F.,Fleming, P.R.; Novel Inhibitors of Bacterial Methionine Aminopeptidase with Broad-Spectrum Biochemical Activity; To be Published,

Experimental method

X-RAY DIFFRACTION (1.43 Å)