4Z7M

Novel Inhibitors of Bacterial Methionine Aminopeptidase with Broad-Spectrum Biochemical Activity

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Methionine aminopeptidase	polymer	261	28995.4	2	UniProt (P0AE20) Pfam (PF00557) UniProt (by SIFTS) (P0AE18)	Escherichia coli	MetAP, Peptidase M, MAP
2	C, E (A, B)	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
3	D, F (A, B)	N~2~-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide	non-polymer		441.5	2	Chemie (4L9)
4	G, H (A, B)	water	water		18.0	387	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	57990.9
Non-Polymers*	Number of molecules	4
	Total formula weight	992.8
All*	Total formula weight	58983.7

*Water molecules are not included.