4Z3O
Quinolone(Moxifloxacin)-DNA cleavage complex of topoisomerase IV from S. pneumoniae
Summary for 4Z3O
Entry DOI | 10.2210/pdb4z3o/pdb |
Related | 3KSA 3KSB 3RAD 3RAE 3RAF 4I3H 4KOE 4PXP |
Descriptor | DNA topoisomerase 4 subunit B,ParE30-ParC55 fused topo IV from S. pneumoniae, E-site DNA, MAGNESIUM ION, ... (8 entities in total) |
Functional Keywords | topo iv, cleavage complex, dna, quinolone, isomerase |
Biological source | Streptococcus pneumoniae More |
Cellular location | Cell membrane ; Peripheral membrane protein : P72525 |
Total number of polymer chains | 6 |
Total formula weight | 180264.19 |
Authors | Laponogov, I.,Veselkov, D.A.,Pan, X.-S.,Selvarajah, J.,Crevel, I.M.-T.,Fisher, L.M.,Sanderson, M.R. (deposition date: 2015-03-31, release date: 2016-09-14, Last modification date: 2024-01-10) |
Primary citation | Laponogov, I.,Veselkov, D.A.,Pan, X.-S.,Selvarajah, J.,Crevel, I.M.-T.,Fisher, L.M.,Sanderson, M.R. Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae To Be Published, |
Experimental method | X-RAY DIFFRACTION (3.44 Å) |
Structure validation
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