4Z3O
Quinolone(Moxifloxacin)-DNA cleavage complex of topoisomerase IV from S. pneumoniae
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | DNA topoisomerase 4 subunit B,ParE30-ParC55 fused topo IV from S. pneumoniae | polymer | 742 | 84211.4 | 2 | UniProt (Q59961) UniProt (P72525) Pfam (PF01751) Pfam (PF00986) Pfam (PF00521) In PDB | Streptococcus pneumoniae | Topoisomerase IV subunit B |
2 | E | E-site DNA | polymer | 7 | 2121.4 | 1 | Escherichia coli | ||
3 | F | E-site DNA | polymer | 11 | 3348.2 | 1 | Escherichia coli | ||
4 | G | E-site DNA | polymer | 7 | 2113.4 | 1 | Escherichia coli | ||
5 | H | E-site DNA | polymer | 11 | 3358.2 | 1 | Escherichia coli | ||
6 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
7 | F, H | 1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | non-polymer | 401.4 | 2 | Chemie (MFX) | |||
8 | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
A, B: 404 - 995 (UniProt: Q59961)
A, B: 1003 - 1484 (UniProt: P72525)
PDB | External Database | Details |
---|---|---|
Met 403 | - | expression tag |
Ile 460 | Val 460 | engineered mutation |
Ala 996 | - | linker |
Thr 997 | - | linker |
Val 998 | - | linker |
Phe 999 | - | linker |
His 1000 | - | linker |
Met 1001 | - | linker |
Ser 1002 | - | linker |
PDB | External Database | Details |
---|---|---|
Thr 1257 | Ile 257 | engineered mutation |
Thr 1485 | - | expression tag |
Ala 1486 | - | expression tag |
Lys 1487 | - | expression tag |
Ala 1488 | - | expression tag |
Leu 1489 | - | expression tag |
Glu 1490 | - | expression tag |
His 1491 | - | expression tag |
His 1492 | - | expression tag |
His 1493 | - | expression tag |
His 1494 | - | expression tag |
His 1495 | - | expression tag |
His 1496 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 179364.1 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 900.1 | |
All* | Total formula weight | 180264.2 |