4Z3K

Human sepiapterin reductase in complex with the cofactor NADP+ and the trypthophan metabolite xanthurenic acid

Summary for 4Z3K

• Entry DOI: 10.2210/pdb4z3k/pdb
• Related: 4XWY
• Descriptor: Sepiapterin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Xanthuric acid, ... (6 entities in total)
• Functional Keywords: sepiapterin-reductase, xanthurenic acid, inhibitor, tryptophan-metabolite, oxidoreductase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P35270
• Total number of polymer chains: 4
• Total formula weight: 123998.39

Authors

Johnsson, K. (deposition date: 2015-03-31, release date: 2015-11-18, Last modification date: 2024-01-10)

• Primary citation: Haruki, H.,Hovius, R.,Pedersen, M.G.,Johnsson, K.; Tetrahydrobiopterin Biosynthesis as a Potential Target of the Kynurenine Pathway Metabolite Xanthurenic Acid.; J.Biol.Chem., 291:652-657, 2016; PubMed: 26565027; DOI: 10.1074/jbc.C115.680488

Experimental method

X-RAY DIFFRACTION (2.35 Å)