4Z3K

Human sepiapterin reductase in complex with the cofactor NADP+ and the trypthophan metabolite xanthurenic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Sepiapterin reductase	polymer	275	29891.4	4	UniProt (P35270) Pfam (PF00106)	Homo sapiens (Human)	SPR
2	E, H, M, Q (A, B, C, D)	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	4	Chemie (NAP)
3	F, I, N, R (A, B, C, D)	Xanthuric acid	non-polymer		205.2	4	Chemie (4KL)
4	G, J, K, O, P... (A, B, C, D)	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
5	L (B)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
6	T, U, V, W (A, B, C, D)	water	water		18.0	160	Chemie (HOH)

Sequence modifications

A, B, C, D: -2 - 258 (UniProt: P35270)

PDB	External Database	Details
Met -16	-	initiating methionine
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Glu -9	-	expression tag
Asn -8	-	expression tag
Leu -7	-	expression tag
Tyr -6	-	expression tag
Phe -5	-	expression tag
Gln -4	-	expression tag
Gly -3	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	119565.7
Non-Polymers*	Number of molecules	15
	Total formula weight	4432.7
All*	Total formula weight	123998.4

*Water molecules are not included.