4Z0V
The structure of human PDE12 residues 161-609
Summary for 4Z0V
Entry DOI | 10.2210/pdb4z0v/pdb |
Related | 4Z2B |
Descriptor | 2',5'-phosphodiesterase 12, MAGNESIUM ION, GLYCEROL, ... (4 entities in total) |
Functional Keywords | pde12 2'-5'a eep nuclease, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Mitochondrion matrix : Q6L8Q7 |
Total number of polymer chains | 1 |
Total formula weight | 50233.98 |
Authors | Nolte, R.T.,Wisely, B.,Wang, L.,Wood, E.R. (deposition date: 2015-03-26, release date: 2015-06-17, Last modification date: 2023-09-27) |
Primary citation | Wood, E.R.,Bledsoe, R.,Chai, J.,Daka, P.,Deng, H.,Ding, Y.,Harris-Gurley, S.,Kryn, L.H.,Nartey, E.,Nichols, J.,Nolte, R.T.,Prabhu, N.,Rise, C.,Sheahan, T.,Shotwell, J.B.,Smith, D.,Tai, V.,Taylor, J.D.,Tomberlin, G.,Wang, L.,Wisely, B.,You, S.,Xia, B.,Dickson, H. The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. J.Biol.Chem., 290:19681-19696, 2015 Cited by PubMed: 26055709DOI: 10.1074/jbc.M115.653113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.78 Å) |
Structure validation
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