4Z09

Crystal structure of FVO strain Plasmodium falciparum AMA1 in complex with the RON2hp [Thr2040Ala] peptide

Summary for 4Z09

• Entry DOI: 10.2210/pdb4z09/pdb
• Related: 4Z0D 4Z0E 4Z0F
• Descriptor: Apical membrane antigen 1, Rhoptry neck protein 2, GLYCEROL, ... (4 entities in total)
• Functional Keywords: cell invasion, inhibitor, ama1, malaria
• Biological source: Plasmodium falciparum Vietnam Oak-Knoll (FVO); More
• Total number of polymer chains: 2
• Total formula weight: 39908.67

Authors

Wang, G.,McGowan, S.,Norton, R.S.,Scanlon, M.J. (deposition date: 2015-03-26, release date: 2016-08-03, Last modification date: 2023-09-27)

• Primary citation: Wang, G.,Drinkwater, N.,Drew, D.R.,MacRaild, C.A.,Chalmers, D.K.,Mohanty, B.,Lim, S.S.,Anders, R.F.,Beeson, J.G.,Thompson, P.E.,McGowan, S.,Simpson, J.S.,Norton, R.S.,Scanlon, M.J.; Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction.; J.Mol.Biol., 428:3986-3998, 2016; PubMed: 27422009; DOI: 10.1016/j.jmb.2016.07.001

Experimental method

X-RAY DIFFRACTION (2 Å)